Various Expressions of Coronary Doppler Patterns of Myocardial Bridging

No abstract available.

Increased expression of dopamine receptors and transporter and hypomethylation of dopamine transporter gene in uterine leiomyoma / 대한산부인과학회지

OBJECTIVE: Dopamine plays a key role in the proliferation regulation of the smooth muscle cells. The purpose of this study was to observe the degree of expression of dopamine D1 and D2 receptors and dopamine transporter (DAT) and to evaluate the influence of methylation about control of expression of DAT in uterine leiomyoma and normal myometrial tissue. METHODS: In 20 patients who underwent hysterectomy due to uterine leiomyoma, normal myometrial and leiomyoma specimens were obtained. The expression of dopamine D1 and D2 receptors and DAT was demonstrated by using RT-PCR and immunohistochemistry in each normal myometrium and leiomyoma. Analysis of the DNA methylation status of DAT was conducted using HpaII digestion and the methylation-sensitive PCR. RESULTS: The mRNA level of dopamine D1 receptor was relatively higher in normal myometrium than D2 receptor and it was also unchanged in leiomyomas. However, the mRNA levels of dopamine D2 receptor and DAT in leiomyomas were much higher than normal myometrium. Consistent with elevated mRNA levels, high levels of dopamine receptors protein expression were detected by immunohistochemistry in leiomyomas. The degree of methylation at CpG sites of the area intron 1 of DAT (genomic position, +377 - +888) was decreased in leiomyomas. CONCLUSION: These results suggest that overexpressed dopamine D2 receptor and DAT would be associated with proliferation of human uterine leiomyomas and the methylation status of the CpG island of DAT determines its expression.

The Effect of Growth Hormone on Patients with Growth Hormone Deficiency and Idiopathic Short Stature / 소아과

PURPOSE: This study was designed to evaluate the effect of growth hormones on children with growth hormone deficiency(GHD) or idiopathic short stature(ISS). METHODS: Between January 1988 to July 2003, 45 patients(M26, F19) with GHD and 24 patients (M13, F11) with ISS were enrolled in this study. Height standard deviation score(Ht SDS) for chronological age(CA) and Ht SDS for bone age(BA) were obtained for each patient upon diagnosis and after growth hormone(0.1-0.15 IU/kg) was injected subcutaneously daily. RESULTS: Ht SDS for CA was -2.06+/-0.23 before treatment, -1.60+/-0.21 at one year, -1.52+/-0.23 at two years, -1.61+/-0.28 at three years, -1.60+/-0.31 at four years, and -1.54+/-0.32 at five years, showing a statistically significant increase for five years(P or =0.05). CONCLUSION: Both groups exhibited significant increase in Ht SDS through growth hormone treatment, proving its efficacy. As for the evaluation of growth-related factors, the 1st year increase of Ht SDS was the most important factor in evaluation of growth effect in both groups. However, further study is required to investigate the effect of GH therapy on ISS.

A New 'Y' Shape Partial Laryngectomy for Supraglottic Carcinoma with Anterior Commissure Invasion or Encroachment / 대한이비인후과학회지

BACKGROUND AND OBJECTIVES: Supraglottic partial laryngectomy (SPL) is contraindicated when lower margin of the tumor invades the anterior commissure or encroaches on it. Those cases are usually treated with supracricoid laryngectomy or near- total or total laryngectomy. But all these procedures have to sacrifice innocent true vocal cords, not because of oncological concerns but because of reconstruction concerns. We designed a new Y-shape partial laryngectomy with preserving vocal cords for this particular situation. PATIENTS AND METHODS: Thyrotomy consists of two incisions, upper and lower. The upper incision was made oblique from superior cornu down to the anterior commissure. When this incision was made 5 mm lateral to the midline, it went down to the inferior border of thyroid cartilage. This modification enables resection enbloc anterior commissure region with SPI. specimen. At closure, both ends of the true cord is anchored to the thyrotomy margin. Each lamina is connected with one miniplate with 6 holes. Then the closure is reinforced with elevated thyroid perichondrium and strap muscles. RESULTS: Two patients were treated with this type of surgery. Both had negative surgical margins. In the postoperative period, no specific complications were noted. Roth of them could decannulate and swallow without aspiration on the 20th day following the surgery. They retained their voices from the true vocal cords. CONCLUSION: This new partial laryngectomy technique could apply to supraglottic carcinoma cases with anterior commissure invasion or encroachment without sacrificing true cords. This procedure provides satisfactory swallowing and postoperative phonatoty function even with resection of the supraglottic structure.

A case of Ebstein's anomaly prenatally diagnosed by fetal sonography / 대한산부인과학회잡지

No abstract available.

Acute Renal Failure and Ischemic Bowel Disease Complicated by Acute Pyelonephritis in a Patient with Systemic Lupus Erythematosus / 대한신장학회잡지

Acute infection increases disease activity in patients with systemic lupus erythematosus(SLE) and causes life threatening complication such as acute renal failure or ischemic bowel disease. We here report a case of acute renal failure and ischemic bowel disease complicated by acute pyelonephritis in a patient with SLE. A 19-year-old woman was admitted for high fever and right flank pain. Urine examination revealed acute pyelonephritis. Thrombocytopenia, proteinuria, positive antinuclear antibody and anti-dsDNA, false positive VDRL confirmed SLE. The pyelonephritis improved with antibiotic treatment, but oliguria and abdominal pain and ascites newly developed. Kidney biopsy and abdominal computed tomography revealed lupus nephritis type IV and ischemic bowel disease, respectively. After methylprednisolone and cyclophosphamide treatment, the patient improved.

Congenital Choanal Atresia : Analysis of 7 Cases / 대한이비인후과학회지

BACKGROUND AND OBJECTIVES:Congenital choanal atresia is a relatively uncommon disease whose causes can be explained by embryological etiology. To date, many authors have expressed various opinions about the timing of surgery and surgical approach. We retrospectively analyzed 7 cases of congenital choanal atresia patients to report the treatment results and to propose the timing of surgery and method of surgical approach. MATERIALS AND METHODS: Seven congenital choanal atresia patients who had been treated between 1981 to 1997 were retrospectively analyzed with chart and X-ray review. The symptoms, associated anomalies, site of atresia, features of the atretic plate, surgical approaches, duration and materials for stenting, reoperation, duration and results of follow-up were analyzed. Five patients were female and 2 patients were male. Associated anomalies were observed in 1 case (14%). Of the 6 patients who underwent surgery, the transnasal approach was used in 3 cases and the transpalatal approach was used in 3 cases. The atretic site was bilateral in 5 cases (71%) and unilateral in 2 cases (29%). Stent was used in all surgical cases. RESULTS: Bony atresia was observed in 3 sides (30%), membranous atresia in 2 sides (20%), and mixed bony-membranous atresia in 5 sides (50%) out of 10 sides evaluable. Three patients who were treated by transpalatal approach and 1 patient who was treated by transnasal approach were successfully treated without reoperation. Two newborn patients who were treated by transnasal approach could achieve normal growth and development due to mouth feeding and nasal breathing. They had granulation tissue or stenosis of the opening but they were successfully treated by reoperation and longer period of stenting. CONCLUSION: We recommend neonatal congenital choanal atresia patient would be better to be treated by transnasal approach with longer period of stenting as soon as possible right after diagnosis.